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职业迁徙
个人简介
She has a strong background in cancer and DNA damage research going all the way back to the beginning of her career. In her postdoctoral research, in Switzerland, she acquired expertise in the field of nucleolar biology and in her current work she bridges these two fields of research in the investigations of genome maintenance of the nucleolus.
Cancer and DNA damage are intimately linked: Genomic instability is a fundamental feature of cancer, most carcinogens generate DNA damage and inherited defects in the cellular DNA damage response (DDR) frequently predisposes to cancer. Furthermore, genomic instability that is a consequence of unrepaired or mis-repaired DNA damage fuels tumour heterogeneity that enhance the chances of acquired treatment resistance and acquisition of metastatic phenotype.
Understanding DNA damage and the cellular response to it is therefore a central aspect of understanding cancer and potentially manipulate the checkpoints and/or DNA repair pathways therapeutically.
Cancer and DNA damage are intimately linked: Genomic instability is a fundamental feature of cancer, most carcinogens generate DNA damage and inherited defects in the cellular DNA damage response (DDR) frequently predisposes to cancer. Furthermore, genomic instability that is a consequence of unrepaired or mis-repaired DNA damage fuels tumour heterogeneity that enhance the chances of acquired treatment resistance and acquisition of metastatic phenotype.
Understanding DNA damage and the cellular response to it is therefore a central aspect of understanding cancer and potentially manipulate the checkpoints and/or DNA repair pathways therapeutically.
研究兴趣
论文共 25 篇作者统计合作学者相似作者
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Moriah R. Arnold,Gabriel M. Cohn,Kezia Catharina Oxe, Somarr N. Elliott, Cynthia Moore, Peter V. Laraia,Sahar Shekoohi, Dillon Brownell, Charles K. Meshul,Stephan N. Witt,Dorthe H. Larsen,Vivek K. Unni
biorxiv(2024)
Cell reportsno. 1 (2023): 111979-111979
Cintia Checa-Rodriguez, Beatriz Suarez-Quintero, Laura Contreras, Lea Korsholm,Dorthe Helena Payne-Larsen, Jesus de la Cruz Diaz,Jiri Bartek,Daniel Gomez-Cabello
biorxiv(2023)
Dorthe H. Larsen,Hua Li, Samikshya Shrestha,Julian C. Verdunk,Celine C.S. Nicole,Leo F. M. Marcelis,Ernst Woltering
Social Science Research Network (2021): 852654
Research Square (2020)
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