Workshop: A maximum likelihood method for quasispecies spectrum assembly

Nicholas Mancuso,Bassam Tork,Pavel Skums,Lilia Ganova-Raeva,Ion Mandoiu,Alex Zelikovsky

Computational Advances in Bio and Medical Sciences（2012）

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摘要

RNA viruses depend on error-prone RNA polymerase for replication within an infected host. These errors lead to a high mutation rate which creates a highly diverse population of related variants [1]. This viral population is known as a quasispecies. As breakthroughs in next-generation sequencing have allowed for researchers to apply sequencing to new areas, studying genomes of viral quasispecies is now realizable. By understanding the quasispecies, more effective drugs and vaccines can be manufactured as well as cost-saving metrics for infected patients [2] implemented.

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关键词

next-generation sequencing,viral population,infected patient,viral quasispecies,cost-saving metrics,error-prone rna polymerase,effective drug,maximum likelihood method,quasispecies spectrum assembly,rna virus,diverse population,infected host,mutation rate,next generation sequencing,maximum likelihood,spectrum,maximum likelihood estimation,microorganisms

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