Vascular

10 1.05 (0.68-1.18) 120 0.97 (0.79-1.13) 240 1.01 (0.73-1.16) GMCD 1.03 (0.96-1.06) GMO 1.00 (0.98-1.01) GMV 1.00 (1.00-1.00) Conta'ol Ischaemic 0.08 (0.01-0.13) 0.04 (0.00-0.07) 0.29 (0.09-0.59) 0.02 (0.01-0.07) 0.05 (0.01-0.14) 0.03 (0.00-0.07) 0.15 (0.13-0.16) 0.45 (0.60-0.49) 1.23 (1.09-1.37) 1.01 (0.99-1.03) 0.53(0.33-0.61) 1.00(1.00-1.00) Post-ischaemic GMBF in C demonstrated low reflow (10 min: p<0.01 v N, ns v I), relative reperfnsion (120 rain: p<0.05 v N, I), mad reperfusion injury (240 min: p<0.01 v N, ns v I) and was associated with muscle infarction and oedema (c v N, I: p<0.01 ). Ischaemia per se did not cause these changes end although capillary density was reduced (p<0.01 v N) it remained greater then in controls (p<0.01). This model demonstrates SMRI end is suitable for exploring both its pathogenesis and pharmacological manipulation.