An approach to the treatment of severe adult respiratory failure

Objectives:The purpose of this article is to evaluate outcome in adult patients with severe respiratory failure managed with an approach using (1) limitation of end inspiratory pressure, (2) inverse ratio ventilation, (3) titration of PEEP by Svo2, (4) intermittent prone positioning, (5) limitation of Fio2, (6) diuresis, (7) transfusion, and (8) extracorporeal life support (ECLS) if patients failed to respond.