Gene amplification and protein overexpression of HER-2/neu in human extrahepatic cholangiocarcinoma as detected by chromogenic in situ hybridization and immunohistochemistry: its prognostic implication in node-positive patients

H. J. Kim,T. W. Yoo,D. I. Park,J. H. Park,Y. K. Cho,C. I. Sohn,W. K. Jeon,B. I. Kim,M. K. Kim,S. W. Chae,J. H. Sohn

Annals of Oncology（2007）

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摘要

Background: In cholangiocarcinoma (CC), HER-2/neu protein overexpression has rarely been reported and the results are conflicting. The present study aimed to clarify the rates of HER-2/neu protein overexpression and gene amplification in human extrahepatic CC and to evaluate the correlation between HER-2/neu and several clinicopathologic features.

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chromogenic in situ hybridization,extrahepatic cholangiocarcinoma,HER-2/neu,immunohistochemistry

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