Leptin treatment increases suppressors of cytokine signaling in central and peripheral tissues.
FEBS Letters(1999)
摘要
Leptin concentrations are elevated in the majority of obese individuals raising the possibility that leptin resistance contributes to their obesity. Peripheral leptin administration for 48 h caused a several-fold increase in mRNA encoding the suppressors of cytokine signaling SOCS-3 and CIS in hypothalamus and peripheral tissues. Paradoxically, CIS and SOCS-3 mRNAs are also elevated in the leptin-deficient ob/ob mouse. Forced expression of CIS in insulinoma cells prevented transactivation mediated by leptin. Thus tissues continuously exposed to leptin and/or other factors associated with obesity accumulate excessive amounts of SOCS-3 and CIS which could provide a potential mechanism for leptin resistance.
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关键词
Leptin,Signal transducer and activator of transcription,Suppressor of cytokine signaling,Cytokine-inducible SH2-containing protein,Leptin resistance
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