Gene Context and DNA rearrangements in the carbapenemase locus of division II strains of Bacteroides fragilis.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY(2009)

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摘要
The cfiA gene is clustered in a bicistronic operon encoding an N-acetyltransferase and an O-acetyltransferase related to resistance markers. This genetic context, exclusively found in strains of Bacteroides fragilis division II, has been highly rearranged by the successive integration of two new mobile sequences, a miniature element and ISBf9. Besides that, among the DNA polymorphisms detected in the cfiA locus, only the integration of IS942 at its promoter was a determinant for expression of carbapenemase activity.
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关键词
genetic analysis,drug resistance,enzyme activity,genetic variation,enzymes,loci,genes,alleles
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