Novel and potent calcium-sensing receptor antagonists: discovery of (5R)-N-[1-ethyl-1-(4-ethylphenyl)propyl]-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide monotosylate (TAK-075) as an orally active bone anabolic agent.

Bioorganic & Medicinal Chemistry（2011）

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摘要

Discovery of novel and potent tetrahydropyrazolopyrimidine derivatives as an orally active bone anabolic agent are reported.

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关键词

Orally active,Calcium-sensing receptor antagonists,CaSR,Bone anabolic agents,PTH,TAK-075

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