Altered arachidonic acid metabolism via COX-1 and COX-2 contributes to the endothelial dysfunction of penile arteries from obese Zucker rats.

A Sánchez,C Contreras,N Villalba,P Martínez, A C Martínez, A Bríones,M Salaíces, A García-Sacristán,M Hernández,D Prieto

British Journal of Pharmacology（2010）

引用 27|浏览4

暂无评分

摘要

Vasoactive prostanoids were formed via constitutively active COX-1 and COX-2 pathways in normal rat penile arteries. Under conditions of insulin resistance, the release and/or effects of vasodilator prostanoids were impaired, contributing to the blunted endothelium-dependent vasodilatation and to the enhanced vasoconstriction.

查看译文

关键词

insulin resistance,penile arteries,endothelial dysfunction,arachidonic acid,COX-1,constitutive COX-2,obese Zucker rat

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要