Tamoxifen as Prophylaxis for Prevention of Gynaecomastia and Breast Pain Associated with Bicalutamide 150mg Monotherapy in Patients with Prostate Cancer: A Randomised, Placebo-Controlled, Dose–Response Study

Yves Fradet,Blair Egerdie,Morten Andersen,Teuvo L.J. Tammela,Mahmoud Nachabe,Jon Armstrong,Thomas Morris,Sunil Navani

European Urology（2007）

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摘要

Bicalutamide 150mg is effective in locally advanced prostate cancer; however, it is associated with a high incidence of breast pain and gynaecomastia. These effects can be reduced prophylactically with tamoxifen at an effective dose of 20mg daily.

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关键词

Bicalutamide,Breast pain,Gynaecomastia,Management,Nonsteroidal antiandrogen,Prophylaxis,Prostate cancer,Tamoxifen

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