Stereospecific synthesis ofl -2-amino-3-(7-methoxy-4-coumaryl)propionic acid, an alternative to tryptophan in quenched fluorescent substrates for peptidases
Letters in Peptide Science(1998)
摘要
Summary A ligh-yielding synthesis of the highly fluorescent amino acidl-2-amino-3-(7-methoxy-4-coumaryl)propionic acid (l-Amp) has been developed via (2R)-bormane-10,2-sultam glycinate.l-Amp facilitates the synthesis of sensitive fluorogenic proteinase substrates with N-terminal solubilising or reactive group.
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