Histological Analysis of Tissue Ingrowth and Organization Following Implantation of a Novel Synthetic Acellular Meniscal Scaffold for the Treatment of Irreparable Partial Meniscus Tears and/or Partial (SS-27A)

Conclusion No signs of tissue necrosis or cell death were observed and all biopsies showed complete re-population by cells and tissue that can be regarded as vital structures, illustrating the biocompatibility of the polyurethane scaffold. Importantly, the layered organization of biopsied scaffold meniscus, each with its own histological characteristics, is illustrative of an ongoing process of regeneration, maturation, and remodeling. Moreover, the above-described structures and their organization are similar to that of the native human meniscus. (Actifit Study Group: R. Verdonk, P. Beaufils, J. Bellemans, P. Colombet, R. Cugat, P. Djian, H. Laprell, P. Neyret, H. Paessler.)