Interleukin 1 genotypes in multiple sclerosis and relationship to disease severity
Journal of Neuroimmunology(2002)
摘要
We studied the association between clinical outcome in MS and allelic variants single nucleotide polymorphisms (SNPs) of interleukin-1α (IL-1α), IL-1β and a variable number tandem repeat (VNTR) in IL-1 receptor antagonist (IL-1RN). A total of 377 patients with MS were studied. Significant associations between IL-1 genotypes and clinical outcome were found using logistic regression after correction for gender, onset age and disease duration. The same trends were subsequently demonstrated in a second independent group of 67 primary progressive patients. Our results suggest that genetically determined immunomodulation mediated by IL-1 influences long-term prognosis in multiple sclerosis (MS).
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关键词
Multiple sclerosis,Interleukin-1,Interleukin-1 receptor antagonist,Severity,Linkage disequilibrium,SNP
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