Effect Of Resistance Exercise On Dehydroepiandrosterone Sulfate Concentration And Glycemia During Recovery: 1462

Serum dehydroepiandrosterone sulfate (DHEA-S) concentration is known to associate with the whole-body insulin sensitivity. PURPOSE: The main purpose of the study was to investigate the effect of resistance exercise on DHEA-S concentration during a 72-h postexercise recovery, and its relation to glucose tolerance and insulin sensitivity. METHODS: Serum samples was obtained from 19 male volunteers (aged 21.2± 0.4 years) 24 h before the onset of exercise and 24 h, 48 h, and 72 h following exercise for measurements of DHEA-S, cortisol, and TNF-a. Oral glucose tolerance test (OGTT) and insulin response were determined 24 h before and 48 h after exercise. RESULTS: We found that exercise significantly suppressed serum DHEA-S levels during recovery (48 h and 72 h). The resistance exercise did not affect glucose tolerance, but insulin response during OGTT was significantly elevated. The increased insulin level was not associated with serum levels of cortisol and TNF-a. CONCLUSIONS: The present study found that resistance exercise has a DHEA-S lowering effect persisted for 72 h. This change appears to be related to the elevated insulin concentrations during OGTT.