Pathogenic aspects of urethral diverticula in females

The incidence of diverticular disease of the female urethra varies between 1.8% and 5%. Although the disease was described 300 years ago, there is still debate on its pathogenesis. Sterile urinalysis, preferably localization in the distal urethra at the site where the embryonic layers meet, and the mostly smooth walls with a rounded shape in most of our patients, point toward an inborn defect rather than an inflammatory etiology secondary to infection and obstetrical complications.