583. Evaluation of a pDNA-Based Anthrax Vaccine and Immune Correlates of Protection in Mice and Non-Human Primates

Peggy Lalor,Vanessa Whitlow,C. Richard Lyons,Julie Lovechik,Mark R. Perry,Jane Morrow,Peter Hobart,Holly Horton,Larry Smith,David Kaslow,Alain Rolland

MOLECULAR THERAPY（2006）

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摘要

VCL-AB01 is a bivalent plasmid DNA (pDNA)-based anthrax vaccine candidate (composed of pDNA encoding detoxified Protective Antigen (PA) and Lethal Factor (LF) formulated with a cationic lipid system) currently in a Phase 1 trial. The immunogenicity and protective efficacy of this investigational vaccine were evaluated in lethal B. anthracis spore challenge mouse and NHP models.

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antibody titer,pharmacology

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