A Synthetic Protein Selected for Ligand Binding Affinity Mediates ATP Hydrolysis

Acs Chemical Biology, Volume 4, Issue 8, 2009, Pages 649-658.

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Abstract:

How primitive enzymes emerged from a primordial pool remains a fundamental uranswered question with Important practical implications in synthetic biology. Here we show that a de novo evolved ATP binding protein, selected solely on the basis of its ability to bind ATP, mediates the regiospecific hydrolysis of ATP to ADP when crystallized w...More

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