Calcium-dependent oligonucleotide antagonists specific for L-selectin

JOURNAL OF INVESTIGATIVE MEDICINE, no. 3 (1996): A293-A293

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The selectins are calcium-dependent C-type lectins that recognize complex anionic carbohydrate ligands, initiating many cell-cell interactions in the vascular system. Selectin blockade shows therapeutic promise in a variety of inflammatory and postischemic pathologies. However, the available oligosaccharide ligand mimetics have low affini...更多

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