Animal Models for Benign Prostatic Hyperplasia
Handbook of experimental pharmacology(2011)
摘要
Although the etiology of benign prostatic hyperplasia (BPH) is unknown, various animal models have been used for several decades
to identify potential therapeutic approaches. These models can be divided into those measuring smooth muscle tone and those
measuring cellular proliferation. Animal models have played an important role in the development of the two drug classes currently
approved for the treatment of BPH: the α-adrenoceptor antagonists and the steroid 5-α-reductase inhibitors. However, models
measuring prostatic tone have not been particularly useful in the identification of new α-adrenoceptor antagonists having
advantages over currently available drugs, and it is not certain that reduction of prostatic smooth muscle tone is responsible
for the relief of BPH symptoms. A further limitation with BPH models is that prostatic hyperplasia similar to the human condition
does not occur spontaneously or cannot be induced in any suitable animal species. The identification of a more useful BPH
model is focused on cellular mechanisms of prostatic growth, looking similarities between humans and experimental animals.
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