PROSTACYCLIN FORMATION BY THE PREGNANT HUMAN MYOMETRIUM
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY(1980)
摘要
Human myometrium taken between 15 and 42 weeks of pregnancy released a material in vitro which possessed anti-aggregatory activity. This material parallelled authentic prostacyclin in this action; it possessed a similar stability at alkaline pH and generation of activity was inhibited by indomethacin. Production of the prostacyclin-like material by the myometrium was similar at weeks 15 and 38 of pregnancy but a 4-fold increase in synthesis had occurred by 40 weeks. It is suggested this increase may be important for parturition.
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关键词
prostacyclin formation
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