Quaternary Substituted Pde Iv Inhibitors Ii: the Synthesis and in Vitro Evaluation of A Novel Series of Gamma-Lactams
Bioorganic & medicinal chemistry letters(1998)
摘要
This communication describes the synthesis and in vitro evaluation of a novel potent series of phosphodiesterase type (IV) (PDE IV) inhibitors. Several of the quaternary substituted lactams presented possess low nanomolar IC50's for PDE IV inhibition.
更多查看译文
关键词
cAMP Signaling
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要