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Serum Hepatocyte Growth Factor Levels Predict Long-Term Clinical Outcome after Percutaneous Coronary Revascularization.

European heart journal(2005)

INSERM-ESPRI Department of Hematology | INSERM-ESPRI Department of Cardiology | University Hospital Department of Biochemistry | Institut Pasteur INSERM-U508 | University Hospital Department of Cardiology | Hop Cardiol

Cited 29|Views63
Abstract
AIMS:To evaluate, in patients referred for elective percutaneous coronary revascularization (PCR) without heparin pre-treatment, the relationship between baseline serum levels of the angiogenic growth factors, vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF), and clinical outcome.METHODS AND RESULTS:In 488 consecutive patients undergoing elective coronary angioplasty, hsC-reactive protein, HGF, and VEGF levels were measured before heparin administration. The primary endpoint, a composite of death and myocardial infarction, occurred in 44 patients at a median follow-up of 14.9 months. At baseline, VEGF levels were related to C-reactive protein levels and inversely related to age; HGF levels were related to C-reactive protein levels, diabetes, and recent clinical instability. In the univariate analysis, HGF had a significant positive relationship (P=0.003) with the primary endpoint. A similar trend was observed for VEGF (P=0.11). The only three variables significantly associated with the primary endpoint in the multivariable Cox model were HGF (P=0.004), C-reactive protein (P=0.007), and diabetes (P=0.04).CONCLUSION:Our results demonstrate that in patients, without heparin pre-treatment, referred for PCR, a high serum level of HGF is an independent predictor of clinical events during follow-up and is correlated with other surrogate measures of the activity of atherosclerosis.
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angioplasty,growth factors,diabetes mellitus,C-reactive protein,clinical outcome
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要点】:该论文研究了在未接受肝素预处理的患者中,基线血清肝细胞生长因子(HGF)水平与经皮冠状动脉介入治疗(PCR)后长期临床结局的关系,发现高水平的HGF是临床事件的独立预测因子。

方法】:通过测量488名接受选择性冠状动脉成形术的患者在肝素使用前的血清高敏C反应蛋白、HGF和血管内皮生长因子(VEGF)水平,分析这些指标与临床结局的关联。

实验】:在中位随访14.9个月后,44名患者发生了主要终点事件(死亡和心肌梗死)。单变量分析显示,HGF与主要终点事件有显著的正相关性(P=0.003),而多变量Cox模型中,仅HGF(P=0.004)、C反应蛋白(P=0.007)和糖尿病(P=0.04)与主要终点事件显著相关。