Serum Hepatocyte Growth Factor Levels Predict Long-Term Clinical Outcome after Percutaneous Coronary Revascularization.

S Susen,K Sautiere,F Mouquet,F Cuilleret,A Chmait,EP McFadden,B Hennache,F Richard,P de Groote,JM Lablanche,J DallongevilleTop Scholar,C BautersTop Scholar,B Jude,E Van BelleTop Scholar

European heart journal（2005）SCI 1区

Cited 29|Views63

Abstract

AIMS:To evaluate, in patients referred for elective percutaneous coronary revascularization (PCR) without heparin pre-treatment, the relationship between baseline serum levels of the angiogenic growth factors, vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF), and clinical outcome.METHODS AND RESULTS:In 488 consecutive patients undergoing elective coronary angioplasty, hsC-reactive protein, HGF, and VEGF levels were measured before heparin administration. The primary endpoint, a composite of death and myocardial infarction, occurred in 44 patients at a median follow-up of 14.9 months. At baseline, VEGF levels were related to C-reactive protein levels and inversely related to age; HGF levels were related to C-reactive protein levels, diabetes, and recent clinical instability. In the univariate analysis, HGF had a significant positive relationship (P=0.003) with the primary endpoint. A similar trend was observed for VEGF (P=0.11). The only three variables significantly associated with the primary endpoint in the multivariable Cox model were HGF (P=0.004), C-reactive protein (P=0.007), and diabetes (P=0.04).CONCLUSION:Our results demonstrate that in patients, without heparin pre-treatment, referred for PCR, a high serum level of HGF is an independent predictor of clinical events during follow-up and is correlated with other surrogate measures of the activity of atherosclerosis.

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Key words

angioplasty,growth factors,diabetes mellitus,C-reactive protein,clinical outcome

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