A TNFR1 genotype with a protective role in familial rheumatoid arthritis.

Philippe Dieudé,José Osorio,Elisabeth Petit-Teixeira, Sarah Moreno,Sophie Garnier,Séverine Cailleau-Moindrault, Caroline Stalens,Sandra Lasbleiz,Thomas Bardin,Bernard Prum,François Cornélis

ARTHRITIS AND RHEUMATISM（2004）

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摘要

We found evidence for an association between RA and a TNFR1 protective genotype, restricted to familial RA. Distribution of the TNFR2 196 R/R and TNFR1 +36 A/A genotypes in familial RA could suggest an interaction between TNFR1 and TNFR2 in the genetic susceptibility for RA.

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