Study of the interaction between nucleic acids and the daunoblastina aluminum (III) complex

In this study, the interactions between aluminum (III)–daunoblastina (DBS) complex and nucleic acids (DNA), and the combination of DBS and Al (III) were studied using ultraviolet (UV)–visible absorption and fluorescence spectra. The experiment results showed that DBS could bind to Al 3+ and that a binary complex DBS–Al 3+ could be formed. The Al 3+ –DBS binary complex could also combine with DNA and a ternary complex Al 3+ –DBS–DNA can be formed. The interaction mode between Al 3+ –DBS complex and DNA is intercalation binding. The binding constant K was 5.8 × 10 3 L/mol and the binding number was 4. Both the melting curve and fluorescence polarization agreed with the above conclusions of the interaction mechanism. This study has significant value for studies of the reduction of DBS’s cardiotoxicity and pharmacological studies of cancer treatments using Al 3+ –DBS as a drug.