Synthesis of chiral analogues of FTY720 and its phosphate

Klaus Hinterding,Sylvain Cottens,Rainer Albert,Frederic Zecri,Peter Buehlmayer,Carsten Spanka,Volker Brinkmann,Peter Nussbaumer,Peter Ettmayer,Klemens Hoegenauer,Nathanael Gray,Shifeng Pan, PB Buehlmayer,SF Pan

SYNTHESIS-STUTTGART（2003）

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摘要

Efficient and versatile protocols for the synthesis of chiral analogues of the novel immunomodulator FTY720 and its phosphate are described. These synthetic procedures allow for broad structural variation and deliver essential tools to further elucidate FTY720's novel mechanism of action.

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关键词

phosphates,sphingolipids,stereoselective synthesis,drugs,chiral auxiliaries

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