Effect Of Pronestyl On Experimental Coronary Occlusion In Hypothermic Dogs

1. 1. This study confirms the deleterious effects of hypothermia on experimental coronary occlusion in dogs. 2. 2. Pronestyl in large doses would appear to give some protection against ventricular fibrillation in hypothermic dogs with ligation of the anterior descending branch of the left coronary artery. 3. 3. Pronestyl in moderate amounts does not prevent fatal arrhythmias if temperatures below 28 °c. are achieved. 4. 4. Prophylactic pronestyl may have a place in clinical hypothermic states and in some patients with acute myocardial infaraction in order to decrease the incidence of ventricular arrhythmias.