Design of a novel class of biphenyl CETP inhibitors.

Zhijian Lu,Joann B Napolitano,Ashleigh Theberge,Amjad Ali,Milton L Hammond,Eugene Tan,Xinchun Tong,Suoyu S Xu,Melanie J Latham,Laurence B Peterson,Matt S Anderson,Suzanne S Eveland,Qiu Guo,Sheryl A Hyland,Denise P Milot,Ying Chen,Carl P Sparrow,Samuel D Wright,Peter J Sinclair

Bioorganic & Medicinal Chemistry Letters（2010）

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摘要

A new class of CETP inhibitors was designed and prepared. These compounds are potent both in vitro and in vivo. The most active compound (12d) has shown an ability to raise HDL significantly in transgenic mouse PD model.

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关键词

CETP inhibitors,HDL-C,Biphenyl

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