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Identification And Manipulation Of The Caprazamycin Gene Cluster Lead To New Simplified Liponucleoside Antibiotics And Give Insights Into The Biosynthetic Pathway

JOURNAL OF BIOLOGICAL CHEMISTRY, no. 22 (2009): 14987-14996

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Caprazamycins are potent anti-mycobacterial liponucleoside antibiotics isolated from Streptomyces sp. MK730-62F2 and belong to the translocase I inhibitor family. Their complex structure is derived from 5'-(beta-O-aminoribosyl)-glycyluridine and comprises a unique N-methyldiazepanone ring. The biosynthetic gene cluster has been identified...更多

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