反相高效液相色谱法测定达美康缓释片中格列齐特的含量
China Modern Medicine(2010)
Abstract
目的:建立以反相高效液相色谱法(HPLC)测定格列齐特缓释片含量的方法。方法:色谱柱为HypersilODSC18色谱柱,流动相为甲醇-水(60∶40),以格列吡嗪为内标物,检测波长为228nm,流速为1.0ml/min。结果:格列齐特在4~64μg/ml浓度范围内线性关系良好(r=0.9998),平均加样回收率为99.83%(RSD=1.04%)。结论:本方法简便、准确、灵敏度高、重现性好,可用于测定格列齐特制剂的含量测定。
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Key words
Gliclazide modified release tablets,RP-HPLC,Content determination
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