Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13
Kevin D. Freeman-Cook,Lawrence A. Reiter,Mark C. Noe,Amy S. Antipas,Dennis E. Danley,Kaushik Datta,James T. Downs,Shane Eisenbeis,James D. Eskra,David J. Garmene,Elaine M. Greer,Richard J. Griffiths,Roberto Guzman,Joel R. Hardink,Fouad Janat,Christopher S. Jones,Gary J. Martinelli,Peter G. Mitchell,Ellen R. Laird,Jennifer L. Liras,Lori L. Lopresti-Morrow,Jayvardhan Pandit,Usa D. Reilly,Donald Robertson,Marcie L. Vaughn-Bowser,Lilli A. Wolf-Gouviea,Sue A. Yocum Bioorganic & Medicinal Chemistry Letters（2007）
摘要
The discovery of novel, selective spirocyclic inhibitors of MMP-13 is reported.
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关键词
Pyrimidinetrione,Matrix metalloprotease,MMP-13,Collagenase-3
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