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Prediction of hot spot residues at protein-protein interfaces by combining machine learning and energy-based methods.

BMC Bioinformatics, no. 1 (2009): 365-365

被引用112|浏览12
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Alanine scanning mutagenesis is a powerful experimental methodology for investigating the structural and energetic characteristics of protein complexes. Individual amino-acids are systematically mutated to alanine and changes in free energy of binding (DeltaDeltaG) measured. Several experiments have shown that protein-protein interactions...更多

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