Synthesis and Practical Use of 1H ‐1,2,3‐Benzotriazole‐5‐carboxaldehyde for Reductive Amination

Mikhail Krasavin,Dmitry Pershin,Denis Larkin,Dmitry Kravchenko

SYNTHETIC COMMUNICATIONS（2006）

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摘要

A reliable synthetic procedure to obtain multigram quantities of 1H-1,2,3-benzotriazole-5-carboxaldehyde has been developed. This material can be used in reductive amination reactions with primary and secondary amines to provide good to excellent yields of the desired products without protection of the starting material.

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关键词

1H-1,2,3-benzotriazole,building blocks,compound libraries,reductive amination

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