Metformin Suppresses Hepatic Gluconeogenesis and Lowers Fasting Blood Glucose Levels Through Reactive Nitrogen Species in Mice
Diabetologia(2010)
摘要
Metformin, the major target of which is liver, is commonly used to treat type 2 diabetes. Although metformin activates AMP-activated protein kinase (AMPK) in hepatocytes, the mechanism of activation is still not well known. To investigate AMPK activation by metformin in liver, we examined the role of reactive nitrogen species (RNS) in suppression of hepatic gluconeogenesis.
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关键词
AMP,AMP-activated protein kinase,Endothelial nitric oxide synthase,Gluconeogenesis,Metformin,Nitric oxide,Peroxynitrite,Reactive nitrogen species
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