Bifurcated, Modular Syntheses Of Chiral Annulet Triazacyclononanes
ORGANIC & BIOMOLECULAR CHEMISTRY(2003)
Abstract
Three chiral 2,6-disubstituted tri-N-methyl azamacrocycles have been prepared by modular methods. These macrocycles were accessed from three chiral 1,4,7-triazaheptanes intermediates that were prepared by two independent routes. The first of these routes involved the benzylamine opening of chiral tosyl aziridines followed by debenzylation but was problematic on solubility grounds. A second, more effective, route was developed which avoided debenzylation by using ammonia in the nucleophilic opening of chiral tosyl aziridines.
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Key words
chemistry,acid,crystal structure,oxidation,ligands,hydrogen peroxide
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