Short-Term Mitomycin C Followed By Long-Term Interferon Alpha 2 Beta For Conjunctiva-Cornea Intraepithelial Neoplasia

Purpose: To report a case of extensive conjunctiva-cornea intra-epithelial neoplasia (CIN) treated topically with mitomycin C (MMC) and interferon (INF)-alpha 2 beta without surgical resection.Methods: Case report.Results: An 82-year-old woman showed an extensive gelatinous red mass in the bulbar conjunctiva with invasion into the caruncle, inferior fornix, and tarsal conjunctiva and extending for 270 degrees of the corneal surface. A diagnosis of CIN was made by surgical biopsy. Surgical excision with safety margins carried the risk of limbal stem cell depletion. A conservative treatment strategy was used with 2 cycles of topical MMC (0.02%), followed by INF-alpha 2 beta eye drops at a dose of 1 million IU/mL, 4 times a day until tumor disappearance. Total resolution was noted after 75 days of treatment with INF, with no clinical evidence of limbal stem cell deficiency. After 1 year of monitoring, no signs of CIN recurrences were observed.Conclusion: MMC (0.02%), followed by INF-alpha 2 beta (1 million IU/mL) 4 times a day, is an effective treatment against highly extensive CIN, in cases where surgical resection with safety margins is unfeasible.