Tumor induction in mice locally irradiated with carbon ions: a retrospective analysis.

Tumor induction in mice legs that were locally irradiated with carbon ions was compared to tumor induction by γ rays after single and fractionated irradiation. A total of 250 tumors were induced in 1104 mice that received carbon-ion doses of 5 through 65 Gy. A total of 77 tumors were induced in 371 mice that received γ-ray doses of 45 through 95 Gy. Of 91 carbon-ion induced tumors examined histolo...