Discovery of a new class of potent, selective, and orally active prostaglandin D2 receptor antagonists.

Kazuhiko Torisu,Kaoru Kobayashi,Maki Iwahashi,Yoshihiko Nakai,Takahiro Onoda,Toshihiko Nagase,Isamu Sugimoto,Yutaka Okada,Ryoji Matsumoto,Fumio Nanbu,Shuichi Ohuchida,Hisao Nakai,Masaaki Toda

Bioorganic & Medicinal Chemistry（2004）

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摘要

N-(p-Alkoxy)benzoyl-2-methylindole-4-acetic acids 2r and 2s were identified as a new class of orally active prostaglandin D2 (PGD2) receptor antagonists.

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关键词

Prostaglandin,DP receptor,Antagonist

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