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Linezolid resistance in Staphylococcus aureus: gene dosage effect, stability, fitness costs, and cross-resistances.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, no. 4 (2008): 1570-1572

Cited: 92|Views29

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pubmed.ncbi.nlm.nih.gov academic.microsoft.com

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gene dosagepoint mutationprotein synthesis

Abstract

Linezolid resistance in Staphylococcus aureus is typically associated with mutations in the 23S rRNA gene. Here we show that the accumulation of a single point mutation, G2576T, in the different copies of this gene causes stepwise increases in resistance, impairment of the biological fitness, and cross-resistance to quinupristin-dalfopris...More

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