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A Potent and Selective Indole N-type Calcium Channel (ca(v)2.2) Blocker for the Treatment of Pain.

Sriram Tyagarajan,Prasun K. Chakravarty,Min Park,Bishan Zhou,James B. Herrington,Kevin Ratliff,Randall M. Bugianesi,Brande Williams,Rodolfo J. Haedo,Andrew M. Swensen,Vivien A. Warren,McHardy Smith,Maria Garcia,Gregory J. Kaczorowski,Owen B. McManus,Kathryn A. Lyons,Xiaohua Li,Maria Madeira,Bindhu Karanam,Mitchell Green,Michael J. Forrest,Catherine Abbadie,Erin McGowan,Shruti Mistry,Nina Jochnowitz,Joseph L. Duffy

Bioorganic & medicinal chemistry letters（2011）

Cited 22|Views61
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Abstract
N-type calcium channels (Ca(v)2.2) have been shown to play a critical role in pain. A series of low molecular weight 2-aryl indoles were identified as potent Ca(v)2.2 blockers with good in vitro and in vivo potency.
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Key words
Pain,N-type calcium channel,Cav2.2 blockers,Indoles,Chung model
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