The discovery of potent and long-acting oral factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs
Bioorganic & Medicinal Chemistry Letters(2011)
摘要
The discovery of potent and long-acting series of orally available factor Xa inhibitors with tetrahydroisoquinoline and benzazepine motifs is described.
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关键词
Factor Xa,Oral inhibitors,Property based design,Structure based design,P450 inhibition
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