Preparation of Substituted Pyrimido[4,5-b]-1,4-benzoxazepines, Thiazepines, and Diazepines via a Pictet—Spengler Cyclization.

Matthew A. J. Duncton,Leon M. II Smith,Sabina Burdzovic-Wizeman,Aaron Burns,Hu Liu,Yunyu Mao,Wai C. Wong,Alexander S. Kiselyov

Cheminform（2006）

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摘要

[GRAPHICS]A synthesis of the title compounds, which have found use as inhibitors of certain receptor tyrosine kinases, was achieved using a Pictet-Spengler cyclization as a key step.

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