Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase.

K. Shankaran,Karla L. Donnelly,Shrenik K. Shah,Ravindra N. Guthikonda,Malcolm MacCoss,John L. Humes,Stephen G. Pacholok, Stephen K. Grant,T. M. Kelly,K. K. Wong

Bioorganic & Medicinal Chemistry Letters（2004）

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摘要

Synthesis and evaluation of pyrrolidin-2-imines (X=CHR1) and 1,3-thiazolidin-2-imines (X=S) as inhibitors of nitric oxide synthase (NOS) are discussed.

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关键词

NOS,Pyrrolidin-2-imine,1,3-Thiazolidin-2-imine

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