Intracellular zinc inhibits KCC2 transporter activity

Michal Hershfinkel,Karl Kandler,Megan E Knoch,Michal Dagan-Rabin,Mandar A Aras, Chen Abramovitch-Dahan,Israel Sekler,Elias Aizenman

NATURE NEUROSCIENCE（2009）

引用 56|浏览24

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摘要

Potassium-chloride co-transporter 2 (KCC2) activity is known to be attenuated by neural injury. Hershfinkel et al . show that KCC2 activity is inhibited by intracellular free zinc, a component of neuronal injury signaling pathways. Oxygen-glucose deprivation results in attenuation of KCC2 activity that is reversible by intracellular zinc chelation.

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关键词

molecular biology,psychophysics,potassium,cortex,physiology,nervous system,cell line,cognitive science,behavior,symporters,synaptic transmission,systems neuroscience,brainstem,intracellular fluid,neuroscience,nature,memory,functional imaging,computation,zinc

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