The effect of ipriflavone on osteopenia in ovariectomized women
Journal of Bone and Mineral Metabolism(1993)
摘要
This study evaluated the preventative effect of ipriflavone on osteopenia in 21 female patients who had either reached natural
menopause or had been bilaterally ovariectomized at least 3 years before the beginning of the study. Out of the 21 patients,
18 had been ovariectomized, 11 of whom were monitored continuously for more than 48 weeks. These 11 patients were divided
into groups A and B. The remaining three patients who reached natural menopause were administered the drug for less than 48
weeks, and were excluded from the study. Ipriflavone 600 mg/day was administered to group A (n=4), and ipriflavone 600 mg
plus ‘Premarin’ 0.625 mg/day to group B (n=7), each day for 48 weeks. The bone mineral density (BMD) of L2–L4 of the subjects
who were monitored continuously for 48 weeks was measured using dual-energy x-ray absorptiometry (DXA) (Norland XR-26). The
BMD of those subjects who received ipriflavone alone decreased only slightly for the first 36 weeks, a smaller decrease than
those who did not, and at 48 weeks a slight improvement appeared. Those subjects receiving ipriflavone plus ‘Premarin’ showed
an increase in BMD at 24 weeks but at 48 weeks the BMD had returned to the pretreatment level. Next we divided groups A and
B into 2 sub-groups (A1, A2; B1, B2) according to their BMD levels following the 48-week treatment. In all groups, there was a tendency for serum osteocalcin,
urinary hydroxyproline/creatinine ratio, and urinary calcium/creatinine ratio to decrease; the decrease in the hydroxyproline/creatinine
ratio was especially evident in groups A1 and B1. Thus, our study suggested ipriflavone, administered alone, had a potentially preventative effect on rapid bone loss in females
who had recently been ovariectomized.
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关键词
ovariectomy,osteopenia,postmenopause,ipriflavone
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