Novel benzimidazole-based MCH R1 antagonists

Andrew J. Carpenter,Kamal A. Al-Barazanji,Kevin K. Barvian,Michael J. Bishop,Christy S. Britt,Joel P. Cooper,Aaron S. Goetz,Mary K. Grizzle,Donald L. Hertzog,Diane M. Ignar,Ronda O. Morgan,Gregory E. Peckham,Jason D. Speake,Will R. Swain

Bioorganic & Medicinal Chemistry Letters（2006）

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摘要

Structure–activity relationships and efforts to optimize pharmacokinetic properties of a class of benzimidazole-based MCH R1 antagonists are described.

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关键词

Melanin-concentrating hormone,MCH,MCH R1,MCH R1 antagonists,Obesity

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