Concomitant eosinophilia, fasciitis, and mycosis fungoides-like reaction with antinuclear autoantibodies in chronic myeloid leukaemia: role of a T-cell clone induced by imatinib

Imatinib is a selective inhibitor of ABL, ARG (ABL-related gene), C-KIT, and platelet-derived growth factor (PDGF) kinases. Common adverse effects include mild to moderate oedema, nausea, vomiting, diarrhoea, muscle cramps, and cutaneous reactions. We report on a case of eosinophilia, fasciitis, and mycosis fungoides-like reaction, which were accompanied by emergence of a circulating T-cell clone and autoantibodies against the nucleus during imatinib treatment.