Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex

Notch-mediated transcriptional activation requires the formation of a ternary complex, consisting of NotchICD, CSL and a Mastermind family member. Nemo-like kinase is shown to negatively regulate Notch signalling and to promote neurogenesis in zebrafish by phosphoprylating Notch1ICD and reducing formation of the ternary complex.