Tissue-specific ceramide response in the chronically hypoxic rat model mimicking cyanotic heart disease.

Fadi F Bitar,Salman Mroueh,Mohamad El Khatib,Hala Bitar,Mohammed Tarrabain,Marwan El Sabban,Mounir Obeid,Michel Nasser,Ghassan S Dbaibo

Prostaglandins & Other Lipid Mediators（2003）

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摘要

Background and Objective: Acute hypoxia is associated with apoptosis and increase in ceramide levels in various organs. To assess the effect of chronic hypoxia on ceramide accumulation in the lungs and kidneys, we utilized an animal model mimicking cyanotic heart disease.

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关键词

Chronic hypoxia,Neonatal rat,Ceramide,Lung,Kidney,Growth

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