Semi-synthetic aristolactams—inhibitors of CDK2 enzyme
Bioorganic & Medicinal Chemistry Letters(2010)
摘要
Several analogs of aristolochic acids were isolated and derivatized into their lactam derivatives to study inhibition in CDK2 assay. The study helped to derive some conclusions about the structure–activity relation around the phenanthrin moiety. Semi-synthetic aristolactam 21 showed good activity with inhibition IC50 of 35nM in CDK2 assay. The activity of this compound was comparable to some of the most potent synthetic compounds reported in the literature.
更多查看译文
关键词
Semi-synthetic analogs,Aristolactams,IC50,SAR
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要