The Process Development of Ravuconazole: An Efficient Multikilogram Scale Preparation of an Antifungal Agent(1)
ORGANIC PROCESS RESEARCH & DEVELOPMENT(2009)
摘要
The development of a safe, robust process for the preparation of ravuconazole (1), an antifungal agent, is described. The discovery and development of procedures enabling the efficient synthesis of multikilogram quantities of 1 and the process demonstration through plant scale preparations are presented. A controlled means to prepare a Grignard reagent and utilization of Fourier Transform Infrared spectroscopy (FTIR) monitoring to safely conduct the reaction is featured.
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关键词
process development
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